A new vaccine offers strong promise against H5N1 bird flu. The clade 2.3.4.4b virus has spread across North America. Bird flu threatens livestock, birds, and human health. New mutations raise serious pandemic concerns.
Researchers developed a nanoparticle vaccine using viral surface proteins. H5 and N1 proteins were displayed on immunogenic liposomes. These proteins help trigger a strong immune response in the body.
Mice received the vaccine and produced antibodies targeting both proteins. All vaccinated mice survived a deadly H5N1 infection. These results suggest the vaccine offers complete protection.